Secretin and cholecystokinin-pancreozymin in combination in the inhibition of gastric acid secretion.
نویسندگان
چکیده
Both secretin, and the single substance which possesses both cholecystokinin and pancreozymin activity, have been shown to inhibit gastric acid secretory responses. Since potentiation may occur between pairs of stimulants of gastric secretion, the effects of combining secretin and cholecystokinin/pancreozymin have been studied in Heidenhain pouches stimulated by continuous intravenous pentagastrin. Evidence suggesting potentiation between these two inhibitor agents is presented.
منابع مشابه
Effect of secretin and cholecystokinin-pancreozymin
The inhibition of gastric motility induced by placing fat in the duodenum was demonstrated to be humoral by Farrell and Ivy (1926). Subsequent studies on extracts of duodenal mucosa have failed to define the substance involved, although the concept that 'enterogastrone' is a duodenal hormone inhibiting both gastric motility and acid secretion is accepted (Grossman, 1950). In recent years, speci...
متن کاملSecretin and cholecystokin / pancreozymin in combination in the inhibition of gastric acid secretion
Inhibition of gastric acid secretion is caused when the mucosa of the upper small intestine is bathed either by fat (Feng, Hou, and Lim, 1929), acid (Sokolov, 1904) or hyperosmolar solutions (Konturek and Grossman, 1965). The studies of Andersson (1960) suggest that the inhibition caused by acid in the duodenum is mediated by a humoral agent. There is therefore interest in the possible inhibito...
متن کاملEffects of secretin, pancreozymin, or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in man.
Intravenous administration of porcine secretin or pancreozymin or synthetic human gastrin II resulted in raised increments in serum immunoreactive insulin during intravenous infusion of glucose in normal man. Enhancement of serum immunoreactive insulin by each hormone was associated with accelerated disposal of glucose. In response to prolonged intravenous infusion of arginine with pancreozymin...
متن کاملEffect of Increasing Dose of Methacholine on Gastric Acid Secretion
It was reported that commercial preparations of both secretin and pancreozymin inhibit gastric acid secretion (Greenlee, Longhi, Guerrero, Nelsen, El-Bedri, and Dragstedt, 1957; Gillespie and Grossman, 1964). Pancreozymin (PZ), in addition, inhibits gastric motility (Johnson and Magee, 1965). Magee and Nakamura (1966), in a preliminary report, have noted that gastric acid is inhibited readily i...
متن کاملAspects of duodeno-gastric reflux in man.
Duodeno-gastric reflux has been studied in normal subjects and patients with duodenal and gastric ulceration during the responses to parenteral secretin and cholecystokinin-pancreozymin and to acidification of the small intestine. Reflux was absent or slight in normal subjects and most patients with duodenal ulcer but was appreciable in most patients with gastric ulcer. Duodeno-gastric regurgit...
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ورودعنوان ژورنال:
- Gut
دوره 12 12 شماره
صفحات -
تاریخ انتشار 1969